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目的:观察帕米膦酸二钠治疗恶性肿瘤骨转移疼痛的疗效及不良反应。方法:将帕米膦酸二钠(博宁)90㎎加入生理盐水500ml中静脉滴注,每月一次。结果:完全缓解(CR)18例,部分缓解(PR)16例,总有效率为77.3%。不良反应少,全组仅有1例患者出现轻微的头晕、乏力,能耐受。结论:帕米膦酸二钠治疗恶性肿瘤骨转移疼痛的疗效好,毒副反应少,且能减轻患者的痛苦,提高其生存质量。
Objective: To observe the efficacy and adverse reactions of pamidronate disodium in the treatment of malignant bone metastases. Methods: Pamidronate disodium (Bonin) 90 ㎎ added 500ml of normal saline intravenously once a month. Results: Eighteen patients with complete remission (CR) and 16 patients with partial remission (PR) had a total effective rate of 77.3%. Less adverse reactions, only 1 patient in the whole group showed slight dizziness, weakness and tolerance. Conclusion: Pamidronate disodium treatment of malignant bone metastases pain is good, less toxic and side effects, and can reduce the pain of patients and improve their quality of life.