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本文对血管生成在肿瘤发生发展中的重要作用加以阐述，针对近年来肿瘤血管新生抑制剂的体内外筛选模型研究方法进行了整理归纳，为进一步探索临床用药提供可靠的实验依据。“,”Inthis paper, its important role in the development of angiogenesis in tumor are discussed. In recent years, we observe some methods of the screening model in vivo and in vitro studies which is targeting tumor angiogenesis inhibitorsin order to provide more reliable experimental basis for clinical medication.