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目的分析2型糖尿病并发肺结核(T2DM-PTB)患者血浆中干扰素-γ(IFN-γ)和白介素-4(IL-4)的分布及其影响因素。方法研究对象分为4组:2型糖尿病并发肺结核组(并发组)、肺结核(PTB)组、2型糖尿病(T2DM)组和健康对照组(Hco组),每组40例。采用酶联免疫吸附(ELISA)法测定各组血浆中IFN-γ和IL-4水平,并采用多元线性回归模型分析影响2者分布的相关因素。结果IFN-γ浓度表现为并发组>TB组>T2DM组>Hco组,组间差异有统计学意义,IL-4在4组间未见差异;血糖控制差、未治疗糖尿病、患糖尿病后减重多、肺部空洞同血浆IFN-γ存在正关联,糖尿病微血管并发症、调查时体质指数与其存在负关联。结论T2DM-PTB患者血浆中Thl/Th2应答有所上调,此上调与血糖控制差、TB病理损伤有关,但2者间孰因孰果尚待研究。
Objective To investigate the distribution and influencing factors of interferon-γ (IFN-γ) and interleukin-4 (IL-4) in patients with type 2 diabetes complicated with pulmonary tuberculosis (T2DM-PTB) Methods The subjects were divided into 4 groups: type 2 diabetes complicated with pulmonary tuberculosis (concurrent group), tuberculosis (PTB) group, type 2 diabetes mellitus (T2DM) group and healthy control group (HCO group), 40 cases in each group. The levels of IFN-γ and IL-4 in plasma were determined by enzyme-linked immunosorbent assay (ELISA). Multivariate linear regression model was used to analyze the influencing factors of the distribution of IFN-γ and IL-4. Results The concentration of IFN-γ was significantly higher than that of the control group (TB group> T2DM group> Hco group). There was no significant difference among the four groups There was a positive correlation between the lung cavity and the plasma IFN-γ, and the microvascular complications of diabetes. There was a negative correlation between body mass index and its existence. Conclusion The plasma Thl / Th2 response is up-regulated in patients with T2DM-PTB, which is related to the poor control of blood glucose and the pathological damage of TB.