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目的观察馥感啉口服液治疗普通型手足口病的疗效。方法选取普通型手足口病患儿120例,随机分为观察组与对照组各60例。2组均接受常规退热、对症处理,对照组予利巴韦林颗粒治疗,观察组予馥感啉口服液治疗。比较2组临床效果、体温恢复时间、皮疹消退时间、T淋巴细胞亚群及安全性和重症转化情况。结果 2组治疗总有效率比较无明显差异(P>0.05),但观察组体温恢复时间与皮疹消退时间均短于对照组(P<0.01);2组治疗后血清CD3~+、CD4~+、CD8~+均高于治疗前(P<0.05),且观察组增高幅度大于对照组(P<0.05);2组均无皮疹、呕吐及腹泻等不良反应发生,无重症转化事件。结论馥感啉口服液治疗普通型手足口病临床效果显著,能有效缩短患儿体温恢复与皮疹消退时间,且药物安全性高,值得临床推广应用。
Objective To observe the curative effect of fluconazole oral solution on common type hand-foot-mouth disease. Methods A total of 120 children with HFMD were selected and randomly divided into observation group (60 cases) and control group (60 cases). Both groups received routine antipyretic, symptomatic treatment, the control group to ribavirin particles, the observation group was treated with flumetrin oral solution. The clinical effects, body temperature recovery time, rash subsidence time, T lymphocyte subsets and safety and severe transformation were compared between the two groups. Results The total effective rate of two groups had no significant difference (P> 0.05), but the recovery time of body temperature and rash subsided time in the observation group were shorter than those in the control group (P <0.01). The levels of CD3 +, CD4 + , CD8 ~ + were higher than those before treatment (P <0.05), and the increase in the observation group was greater than that in the control group (P <0.05). No adverse reaction such as rash, vomiting and diarrhea occurred in the two groups. Conclusion Fu-ling oral solution for the treatment of common hand-foot-mouth disease has significant clinical effect, can effectively shorten the recovery of children’s temperature and rash subsided time, and the drug is safe and worthy of clinical application.