目的:研究更昔洛韦自乳化释药系统,探究其最佳的处方配比。方法:通过溶解度实验对油相、表面活性剂、助表面活性剂进行选择,找到最佳组份;通过三元相图实验,成功地将更昔洛韦包埋于乳液中,得到相应的自乳化区域,并结合乳液粒径的测定寻找出最佳的处方配比。结果:优选的更昔洛韦自乳化释药系统处方中的油相为橄榄油,表面活性剂为聚山梨酯-80,助表面活性剂为聚乙二醇-400。最终确立更昔洛韦自乳化释药系统最优配方为橄榄油-聚山梨酯80-聚乙二醇400(5∶3∶2)。结论:初步成功地制备了更昔洛韦自乳化释药系统制剂。 Objective: To study ganciclovir self-emulsifying drug delivery system and to explore the best prescription ratio. Methods: The optimum conditions were selected by the solubility test, and the best composition was found. Through the experiment of ternary phase diagram, ganciclovir was successfully embedded in the emulsion to obtain the corresponding self - Emulsification area, combined with the determination of emulsion particle size to find the best prescription ratio. Results: The preferred formulation of ganciclovir self-emulsifying drug delivery system was olive oil, surfactant polysorbate -80 and co-surfactant PEG-400. The optimal formulation of ganciclovir self-emulsifying drug delivery system was olive oil-polysorbate 80-polyethylene glycol 400 (5: 3: 2). Conclusion: The ganciclovir self-emulsifying drug delivery system preparation has been initially and successfully prepared.