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Tc-99m-DTPA用于脑、肾的扫描和肾功能的测定。它的制备方法先后已有不少报导。本文报导一种新的改进方法:将0.7毫升DTPA二钠盐(80毫克分子/毫升)加入0.7毫升新鲜制备的SnCl_2溶液(4毫克分子SnCl_2-2H_2O,0.1克分子浓度HCl和2.0克分子浓度NaCl),用稀NaOH溶液调节pH后,冷冻干燥,即得。制剂用凝胶过滤,检查标记产率,采用细颗粒Sephdex G25,展开剂为0.9%NaCl溶液。用体重为220～250克雄性Wistar大鼠进行体内脏器分布研究。静脉注射戊巴比吐进行麻醉后,由尾静脉注入200微居里Tc-99m-DTPA,在不同时
Tc-99m-DTPA for brain, kidney and renal function of the scan. It has prepared a lot of reports. A new and improved method is reported in this paper: 0.7 ml DTPA disodium salt (80 mg / ml) was added to 0.7 ml freshly prepared SnCl 2 solution (4 mM SnCl 2 -2H 2 O, 0.1 mM HCl and 2.0 mM NaCl ), With dilute NaOH solution to adjust pH, freeze-dried, that is, too. The formulation was filtered through a gel and examined for label yield using a fine particle Sephdex G25 with a 0.9% NaCl solution as a developer. In vivo study of organ distribution in male Wistar rats weighing 220-250 g. Intravenous injection of pentobarbital anesthesia, the injection of 200 micro-Curie Tc-99m-DTPA from the tail vein, at different times