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目的研究血小板参数,包括血小板计数(PLT)和平均血小板体积(MPV)与强直性脊柱炎(AS)疾病活动的相关性,探讨其可能的机制。方法测定AS患者治疗前后PLT、MPV,以及急性时相反应物,包括血沉(ESR)、C反应蛋白(CRP)等指标并评估BASDAI和BASFI,比较各指标治疗前后的变化以及各指标之间的相关性,进行统计分析。结果 AS患者治疗后PLT、ESR、CRP测定值及BASDAI和BASFI显著低于治疗前(P<0.05),MPV测定值显著高于治疗前(P<0.05)。治疗前PLT升高组AS患者PLT、ESR、CRP、BASDAI、BASFI等指标均显著高于PLT正常组AS患者(P<0.05),MPV显著低于PLT正常组AS患者(P<0.05)。相关性分析表明PLT和BASDAI、BASFI呈正相关(P<0.05),MPV和BASDAI、BASFI呈负相关(P<0.05)。结论血小板参数PLT、MPV与AS病情活动有关,可作为判断AS疾病活动度的指标。
Objective To study the correlation between platelet parameters, including platelet count (PLT) and mean platelet volume (MPV), and ankylosing spondylitis (AS) disease activity and to explore its possible mechanism. Methods The PLT, MPV and acute phase reactants (including ESR and C-reactive protein (CRP)) in patients with AS before and after treatment were measured, and BASDAI and BASFI were evaluated. The changes of each index before and after treatment, Relevance, statistical analysis. Results The values of PLT, ESR, CRP, BASDAI and BASFI in AS patients were significantly lower than those before treatment (P <0.05), and the MPV values were significantly higher than those before treatment (P <0.05). The PLT, ESR, CRP, BASDAI and BASFI were significantly higher in AS patients with PLT elevation before treatment than those in PLT normal AS patients (P <0.05), and MPV was significantly lower than that in normal PLT AS patients (P <0.05). Correlation analysis showed that there was a positive correlation between PLT and BASDAI and BASFI (P <0.05). There was a negative correlation between MPV and BASDAI and BASFI (P <0.05). Conclusion Platelet parameters PLT and MPV are related to the activity of AS and can be used as an index to judge the activity of AS.