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[目的]观察平肝降压汤联合辛伐他汀与氢氯噻嗪治疗高血压合并高血脂疗效。[方法]使用随机平行对照方法,将80例住院患者按病志号抽签方法随机分为两组。对照组40例辛伐他汀,10mg/d,睡前口服;氢氯噻嗪,25~100mg/d,分成1~2次口服。治疗组40例平肝降压汤(浙贝母4g,甘草6g,车前子、桑叶各10g,菊花12g,荷叶、生山楂、川牛膝、草决明、钩藤、天麻、白术~炒各15g,黄芪~炙20g,茯苓30g;口苦心烦加黄芩、龙胆草、郁金各15g;乏力加香加皮10g,党参~炒15g;便秘加瓜蒌15g;失眠加夜交藤、珍珠母各30g),1剂/d,水煎300mL,早晚口服;西药治疗同对照组。连续治疗15d为1疗程。观测临床症状、舒张压、收缩压、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、不良反应。连续治疗6疗程,判定疗效。[结果]舒张压、收缩压、TG、TC、LDL-C两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01);HDL-C治疗组明显改善(P<0.05),对照组无明显变化(P>0.05)。[结论]平肝降压汤联合辛伐他汀与氢氯噻嗪治疗高血压合并高血脂,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the therapeutic effect of Pinggan antihypertensive Decoction combined with simvastatin and hydrochlorothiazide on hypertension and hyperlipidemia. [Methods] Using randomized parallel control method, 80 inpatients were randomly divided into two groups according to the way of lottery of the disease index. Control group, 40 cases of simvastatin, 10mg / d, bedtime oral; hydrochlorothiazide, 25 ~ 100mg / d, divided into 1 or 2 times orally. Treatment group, 40 cases of Pinggan antihypertensive soup (Fritillaria cirrhosa 4g, licorice 6g, Plantago, mulberry 10g, chrysanthemum 12g, lotus leaf, raw hawthorn, Achyranthes, Cassia, Uncaria, Gastrodia, Atractylodes ~ Fried 15g, Astragalus ~ Sunburn 20g, Poria 30g; mouth pain uprooting plus baicalin, gentian, turmeric 15g; fatigue plus flavoring Jiapi 10g, Codonopsis fried 15g; Vine, mother of pearl 30g), 1 / d, decoction 300mL, morning and evening oral; western medicine treatment with the control group. Continuous treatment 15d for a course of treatment. Clinical symptoms, diastolic blood pressure, systolic blood pressure, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and adverse reactions were observed. Continuous treatment of 6 courses to determine the efficacy. [Results] The diastolic blood pressure, systolic blood pressure, TG, TC and LDL-C were improved in both groups (P <0.05, P <0.01) C treatment group was significantly improved (P <0.05), the control group had no significant change (P> 0.05). [Conclusion] Pinggan antihypertensive Decoction combined with Simvastatin and Hydrochlorothiazide in the treatment of hypertension combined with hyperlipidemia has satisfactory curative effect and no serious adverse reactions, which deserves promotion.