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目的:进一步研究茶多酚(TP)在体外细胞毒作用、体内抗肿瘤的作用。方法:噻唑兰(MTT)体外试验法和灌胃给药体内抗瘤试验。结果:茶多酚对体外培养的人鼻咽癌细胞CNE2、人肺腺癌A549细胞和GLC82细胞及乳腺癌细胞MCF7的半数抑制浓度(IC50)依次为10272μg/ml、3576μg/ml、700μg/ml和6310μg/ml。体内灌胃给予TP125mg/kg、50mg/kg和20mg/kg·d×10天剂量下对小鼠肿瘤L2的抑瘤率依次为3106~3099%、4205~4975%和4512~4679%,P<005~001。TP在125mg/kg、50mg/kg和20mg/kg·d×18天剂量下,对人肺癌裸鼠移植瘤的抑瘤率依次为2977%、3741%和4834%,后二者P<005~001,有显著性意义。结论:茶多酚在体外显示细胞毒作用,体内试验有抗肿瘤作用
Objective: To further study the role of tea polyphenols (TP) in vitro cytotoxicity and in vivo anti-tumor effect. Methods: Thiazide blue (MTT) in vitro test and oral administration of anti-tumor test in vivo. Results: The median inhibitory concentration (IC50) of tea polyphenols on human nasopharyngeal carcinoma cells CNE2, human lung adenocarcinoma A549 cells, GLC82 cells and breast cancer cells MCF7 were 10272 μg / ml, 35 76μg / ml, 700μg / ml and 6310μg / ml. The antitumor rates of mice treated with TP1.25mg / kg, 50mg / kg and 20mg / kg · d × 10days were 3106 ~ 3099% and 4205 ~ 4975% and 4512 ~ 4679%, P <005 ~ 001. The inhibitory rate of TP to xenografts in nude mice bearing human lung cancer were 2977%, 3741% and 48%, respectively, at 125mg / kg, 50mg / kg and 20mg / kg · d × 18days 34%, the latter two P <0 05 ~ 0 01, a significant significance. Conclusion: Tea polyphenols show cytotoxicity in vitro and anti-tumor effect in vivo