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目的探讨血清N末端B型利钠肽原(NT-proBNP)水平对诊断老年患者急性呼吸困难的影响。方法选取2014年3月至2015年8月揭西县人民医院急诊收治的90例急性呼吸困难患者作为研究对象,其中心源性呼吸困难45例,肺源性呼吸困难45例,比较两组患者血清NT-proBNP水平,并分析NT-proBNP水平和左心室射血分数(LVEF)的相关性。结果心源性呼吸困难组患者的血清NT-proBNP水平明显高于肺源性呼吸困难组,LVEF明显低于肺源性呼吸困难组,差异均有统计学意义(均P<0.05);心源性呼吸困难患者血清NT-proBNP水平与LVEF呈负相关(r=-0.768,P<0.01)。结论 NT-proBNP可作为鉴别心源性呼吸困难和肺源性呼吸困难的重要指标,在一定程度上可以判断心力衰竭的程度,且其检测方法简便、快捷。
Objective To investigate the effect of serum NT-proBNP level on the diagnosis of acute respiratory distress in elderly patients. Methods Ninety patients with acute dyspnea who were admitted to the People’s Hospital of Jiexi County from March 2014 to August 2015 were selected as study subjects. Among them, 45 cases were cardio-dyspnea and 45 cases were pulmonary-derived dyspnea. Serum NT-proBNP levels were analyzed and the correlation between NT-proBNP levels and left ventricular ejection fraction (LVEF) was analyzed. Results Serum NT-proBNP levels in patients with cardiogenic dyspnea were significantly higher than those in patients with pulmonary dyspnea and LVEF was significantly lower than those in patients with pulmonary dyspnea (all P <0.05) Serum NT-proBNP levels were negatively correlated with LVEF in patients with dyspnea (r = -0.768, P <0.01). Conclusion NT-proBNP can be used as an important index to differentiate cardiogenic dyspnea and pulmonary-derived dyspnea. To a certain extent, NT-proBNP can determine the degree of heart failure. The detection method is simple and rapid.