溃疡性结肠炎是主要侵犯结肠粘膜与粘膜下层,伴有糜烂和浅表溃疡的、原发的、非特异性炎症性疾患。目前世界保健组织称之为“特发性结肠炎”。其发病率近年来有增长趋势,据横田等人调查,日本1968—1975年有2116例。西欧各国成年人发病率每年为0.5—8人/10万人口。国内发病率一般认为低于国外,病情亦较轻。一、病因病因尚不十分明确,但自身免疫的观点已引起临床广泛重视。本病除腹泻粘液、血便外,常伴有肝脏损害、关节症状等结肠外自身免疫异常表现。部分病例可与系统性红斑狼疮,类风湿性关节炎等自身免疫性疾病合并存在。实验证实本病患者的淋巴细胞对组织培养的胎儿结肠细胞有破坏作用。有 Ulcerative colitis is a primary, nonspecific inflammatory disorder that primarily affects the colon mucosa and submucosa, with erosion and superficial ulcers. Currently World Health Organization called “idiopathic colitis.” Its incidence has increased in recent years, according to Yokota and others survey, Japan 1916-1975 2116 cases. The incidence of adults in Western European countries is 0.5-8 per 100 000 population per year. Domestic incidence is generally considered lower than abroad, the disease is also lighter. First, the etiology is not yet very clear, but the idea of ​​autoimmunity has attracted widespread attention in the clinic. The disease in addition to diarrhea, mucus, bloody stools, often accompanied by liver damage, joint symptoms such as abnormal colon autoimmune manifestations. Some cases may be combined with systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases exist. Experiments confirmed that the patients with lymphocytes on the tissue culture of fetal colon cells have a damaging effect. Have