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目的:探讨表皮生长因子受体(EGFR)在乳腺癌中的表达及临床意义。方法:采用免疫组织化学(S-P)法检测EGFR在47例乳腺癌组织和19例乳腺腺病组织中的表达。结果:47例乳腺癌组织中EGFR阳性表达率为53.2%,显著高于乳腺腺病组织中的表达(26.3%)(P<0.05)。EGFR与乳腺癌的组织学类型及淋巴结转移无明显关系(P>0.05)。结论:EGFR与乳腺癌的发生密切相关,检测EGFR对乳腺癌的早期诊断有重要意义。
Objective: To investigate the expression and clinical significance of epidermal growth factor receptor (EGFR) in breast cancer. Methods: Immunohistochemistry (S-P) was used to detect the expression of EGFR in 47 cases of breast cancer and 19 cases of breast adenosis. Results: The positive rate of EGFR in 47 cases of breast cancer was 53.2%, which was significantly higher than that in breast adenosis (26.3%) (P <0.05). There was no significant correlation between EGFR and histological types and lymph node metastasis (P> 0.05). Conclusion: EGFR is closely related to the occurrence of breast cancer. Detecting EGFR is of great significance in the early diagnosis of breast cancer.