青少年类风湿性关节炎(JRA)是儿童中最常见的风湿性疾病,最近研究表明JRA患者免疫系统处于激活状态,活化的T淋巴细胞可释放可溶性CD_8(sCD_3)抗原和可溶性白细胞介素2受体(sIL-2R)等不同分子。鉴于T淋巴细胞活性与sIL-2R及sCD_8产生之间确实存在着明确的关系,从而推测这两种多肽:sIL-2R与sCD_8可能作为T淋巴细胞活化及JRA活动性的标志。为此作者采用双抗体夹心ELISA法测定受检者血清中sCD_8和sIL-2R水平,藉以证实上述推测,共测49例不发热期的青少年类风湿性关 Juvenile rheumatoid arthritis (JRA) is the most common rheumatic disease in children and recent studies have shown that the immune system is activated in JRA patients and that activated T lymphocytes release soluble CD8 (sCD3) antigens and soluble interleukin 2 Body (sIL-2R) and other different molecules. Given that there is a clear relationship between T lymphocyte activity and the production of sIL-2R and sCD_8, we speculate that these two polypeptides, sIL-2R and sCD_8, may serve as markers of T lymphocyte activation and JRA activity. To this end, the authors used double antibody sandwich ELISA to measure the serum levels of sCD_8 and sIL-2R in order to confirm the above speculation, a total of 49 cases of non-febrile adolescent rheumatoid