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日本京都大学伊藤嘉明等科学家从早期至晚期的46名胃癌患者的切除组织上提取细胞,发现大约60％的早期胃癌患者的“RUNX3”基因停止了活动,而在晚期患者中,这种基因停止活动的高达90％。 “RUNX3”是一种促进分泌消化酶的基因,1995年由伊藤等人发现。使用老鼠进行的动物实验表明,这种基因如果不起作用,细胞数量的调节就会发生障碍,而胃内壁的细胞就会不断地增殖,以致超出正常范围。把这种被破坏了基因的细胞移植到健康的老鼠体内,就会导致胃癌。 科研人员迄今发现了大约10种与胃癌有关的基因,如“P53”等,但是它们致
Kyoto University Japan Ito Kaiming and other scientists from early to late ablation of tissue from 46 patients with gastric cancer cells and found that about 60% of patients with early gastric cancer “RUNX3” gene stopped the activity, and in advanced patients, the gene stops Activities up to 90%. RUNX3 is a gene that promotes the secretion of digestive enzymes and was discovered in 1995 by Ito et al. Animal experiments using mice showed that if this gene does not work, the regulation of the number of cells will be obstacles, and the stomach wall cells will continue to proliferate, which is beyond the normal range. Transplantation of this damaged gene into healthy mice can cause stomach cancer. Researchers so far found about 10 kinds of genes related to gastric cancer, such as “P53”, but they caused