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目的评价经动脉插管灌注5-Fu治疗急性出血坏死性胰腺炎的临床疗效。方法21例急性出血坏死性胰腺炎患者,根据CT检查结果置导管于病变部位的供血动脉。15例置于腹腔动脉,4例置于脾动脉,2例置于胃十二指肠动脉。经导管24h持续灌注5-Fu4～15d。结果21例中,20例经局部动脉药物灌注,病情得到缓解;1例药物灌注后因导管堵塞后改为静脉给药。结论经腹腔动脉插管治疗急性出血坏死性胰腺炎疗效肯定,并发症少,死亡率低,可改善患者的全身状况。
Objective To evaluate the clinical efficacy of transcatheter arterial infusion of 5-Fu in the treatment of acute hemorrhagic necrotizing pancreatitis. Methods Twenty-one patients with acute hemorrhagic necrotizing pancreatitis underwent catheterization at the lesion site based on the CT findings. 15 cases placed in the celiac artery, 4 cases placed in the splenic artery, 2 cases placed in the gastroduodenal artery. The catheter 24h continuous perfusion 5-Fu4 ~ 15d. Results In 21 cases, 20 cases were given local arterial drug infusion, and the disease was relieved. One case of drug infusion was changed to intravenous after the catheter was blocked. Conclusion Intraperitoneal arterial cannulation for acute hemorrhagic necrotizing pancreatitis has certain curative effect, less complications and lower mortality, which can improve the general condition of patients.