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目的:探讨纳洛酮与氨茶碱联用治疗早产儿呼吸暂停的疗效观察。方法:120例呼吸暂停的早产儿采用随机分组的方法分为治疗组及对照组,对照组在给予对症治疗同时单纯应用氨茶碱,治疗组在此基础上加用纳洛酮。结果:对照组总有效率90.3%,治疗组总有效率96.6%,两组对比有显著差异,P<0.01。结论:纳洛酮与氨茶碱联用具有减轻或停止呼吸暂停发作,减轻呼吸暂停时血氧饱和度及心率下降程度,避免缺氧对脑细胞形成损伤,疗效明显优于单纯使用氨茶碱,且安全性高,值得在临床推广。
Objective: To investigate the efficacy of naloxone combined with aminophylline in the treatment of apnea in premature infants. Methods: A total of 120 preterm infants with apnea were randomly divided into treatment group and control group. The control group received aminophylline alone while symptomatic treatment was given. The treatment group received naloxone on this basis. Results: The total effective rate was 90.3% in the control group and 96.6% in the treatment group. There was significant difference between the two groups (P <0.01). Conclusion: The combination of naloxone and aminophylline can reduce or stop apnea, reduce apnea oxygen saturation and heart rate decline, to avoid hypoxia damage to brain cells, the effect is better than the simple use of aminophylline , And high safety, it is worth in the clinical promotion.