作者采用随机、双盲、安慰剂对照、交叉方法评价了环孢霉素(cyclosporin)治疗皮质激素依赖性慢性严重哮喘的疗效。 30例慢性严重哮喘患者,年龄在21～64岁,平均病程27年(4～54年),长期口服皮质激素平均9、3年(强的松龙5～20mg)。30例患者随机先接受本品(最初剂量为每天5mg/kg)或安慰剂12周;此后再进行为期2周的药物冲刷期,接着进行上述治疗的交叉研究。30例患者在进行本研究前,尽管口服 The authors evaluated the efficacy of cyclosporin in the treatment of corticosteroid-dependent chronic severe asthma using a randomized, double-blind, placebo-controlled, crossover approach. 30 patients with chronic severe asthma, aged 21 to 64 years, with an average duration of 27 years (4 to 54 years), long-term oral corticosteroids average 9,3 years (prednisolone 5 ~ 20mg). Thirty patients were randomized to receive the drug (initial dose of 5 mg / kg daily) or placebo for 12 weeks followed by a two-week drug washout period followed by a crossover study of the above treatments. Thirty patients were orally taken prior to the study