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目的:研究分析米索前列醇和盐酸哌替啶对人工流产手术的临床疗效。方法:选取我中心2010年6月-2014年6月期间要求人工流产手术的、孕龄在6-10周的300例患者作为研究对象。随机将这300例患者中的150例作为观察组;术前2小时舌下含服米索前列醇600mg,静脉注射盐酸哌替啶1.5mg/kg5分钟后,常规进行消毒和人工流产负压吸宫术;另外的150例患者作为对照组,直接采用常规负压吸宫术。对比观察两组的治疗效果。结果:观察组的宫颈软化情况、手术时间,出血量,疼痛指数及人流综合症发生率均明显优于对照组。观察组有效率96.3%,对照组有效率57.3%,两组差异明显,具有统计学意义(p<0.05)。结论:人工流产术前2小时使用米索前列醇,手术开始前5min静脉注射盐酸哌替啶,具有宫颈软化扩张好、疼痛轻、子宫收缩好、出血少、手术时间短、人流综合症及子宫穿孔等不良反应的发生少,安全性强,经济适用等优点,值得临床应用和推广。
Objective: To study the clinical effect of misoprostol and meperidine hydrochloride on induced abortion. METHODS: A total of 300 patients with gestational age between 6 and 10 weeks who underwent induced abortion in our center from June 2010 to June 2014 were enrolled in this study. 150 cases of these 300 patients were randomly divided into observation group; 2 hours before operation sublingual misoprostol 600mg intravenous injection of meperidine hydrochloride 1.5mg / kg for 5 minutes, routine disinfection and abortion negative pressure suction Gong surgery; the other 150 patients as a control group, the direct use of conventional suction aspiration. Compare the treatment effect of two groups. Results: Cervical softening, operation time, bleeding volume, pain index and the incidence of human flow syndrome in the observation group were significantly better than those in the control group. The effective rate of the observation group was 96.3%, while that of the control group was 57.3%. There was significant difference between the two groups (p <0.05). CONCLUSION: Misoprostol is used 2 hours before induced abortion and intravenous injection of pethidine hydrochloride 5 minutes before the start of surgery. It has the advantages of good cervix softening and dilatation, light pain, good uterine contractions, less bleeding, shorter operative time, abortion syndrome and uterus Perforation and other adverse reactions occur less, safety, economic advantages, it is worth clinical application and promotion.