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肌肉收缩运动时,细胞内的 ATP 转为 ADP 与AMP,静止时 ATP 又重新合成。但在大运动量或细胞缺血、缺氧时,肌肉的 ATP 降(?)超过合成,出现血浆次黄嘌呤(hypoxanthine,HX)浓度增高。为研究运动时能量代谢情况,作者检测各种运动量下HX 的变化。研究对象为14例健康男性志愿者,平均年龄31(26～35)岁,运动前从前臂浅静脉导管采血测 HX 基值,然后按标准踏车运动逐渐加大运动量。直至最大耐受运动量为止,运动同时不断检测心率,每分钟通气量((?)E)、氧耗量((?)O_2)和 CO_2产生量((?)CO_2),并每5分钟取血测定 HX 共30分钟。结果见最大运动量结束后15分钟,HX 达峰值18.9±2.6μM,显著高于基值1.1±0.1μM。心率、(?)E、(?)O_2、(?)CO_2随运动量的
During muscle contractions, intracellular ATP is converted to ADP and AMP, and ATP is resynthesized at rest. However, in a large amount of exercise or cell ischemia, hypoxia, muscle ATP decreased (?) Over the synthesis, the plasma hypoxanthine (hypoxanthine, HX) concentration increased. To study energy metabolism during exercise, the authors examined changes in HX at various exercise levels. The subjects were 14 healthy male volunteers with an average age of 31 (26-35) years old. HX values were collected from the superficial forearm superciliary catheter before exercise and then gradually increased according to standard treadmill exercise. Until the maximum tolerated exercise, while heart rate, minute ventilation ((?) E), oxygen consumption (? O 2) and CO 2 production HX determination of a total of 30 minutes. As a result, HX peaked at 18.9 ± 2.6 μM 15 minutes after the maximum amount of exercise ended, significantly higher than the baseline value of 1.1 ± 0.1 μM. Heart rate, (?) E, (?) O_2, (?) CO_2 with the amount of exercise