Objective: To investigate 33 organic extracts of mangrove plants for: antiparasitic, anticancer, and antibacterial activities, as well as their ability to inhibit the activity of the a-glucosidase enzyme. Methods: Leaves from all different plant mangrove species located in five mangrove zones of the Pacific coast of Panama were collected according to standard procedures. Qualitative phytochemical analysis of the organic extracts was performed by thin layer chromatography. The antiparasitic activity against Plasmodium falciparum, Tnywosoma cruzi and Leishmaia donovani, toxicity against Artia salina. anticancer activity in MCF-7 cell line, and antibacterial activity against Staphyloccus aureus. Bacillus subtilis, Escherichia coli and Pseudoinonas aeruginosa of all organic extract were investigated according protocols stablished in our institution. Finally, the ability to inhibit the enzymatic activity of a-glucosidase was evaluated by monitoring the hydrolysis of p-nitrophenyl α-D-glucopyranoside. Results: Thirty-three different samples belonging to nine different species of vascular plants with seeds of true mangroves were collected. Triterpenoids, phenolics, and tannins were the main groups of compounds found in the sampled mangroves. Saponins, quinones, and coumarins were found in less than 50％ of the samples. Laguncnlaria racemosa showed moderate activity against Plasmodium falciparum. None of the extracts presented anticancer activity. Rhizophora mangle exhibited potent activity against Staphytococcus aureus and Bacìllus sublilis [(90.41±7.33)％ and (96.02±6.14)％ of inhibition]; Avicenniu germinans and Concarpus erectus had activity against Escherichia coli [(71.17±6.15)％ and (60.60±5.13)％ of inhibition. respectively]. About 60％ of the mangroves showed a-glucosidase inhibitory activity. In particular, extracts from Iagunculariu racemosa, Pelliciera rhizophorae, Conoccarpus erectus, Mora oleifea,and Tabebuia puliistris species showed a-glucosidase inhibitory potential, with IC50 values of (29.45±0.29), (20.60±0.70), (730.06±3.74), (25.59±0.37). and (853.39±5.30) μg/mL, respectively. Conclusions: Panamanian mangroves are mainly a promising potential source of hypoglycemic compounds, specifically a-glucosidase inhibitors. These results highlight the therapeutic virtues of extracts from American mangrove plants.