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在全球消灭脊髓灰质炎进程中，实验室要对大量的标本进行检测。由于病毒株对细胞敏感性的差异，在进行病毒分离鉴定时，ＷＨＯ推荐使用ＲＤ和Ｈｅｐ─２两种细胞株，而这两种细胞不仅对脊髓灰质炎病毒敏感，而且对其它肠道病毒，尤其是一些能致麻痹的肠道病毒也敏感。随着消灭脊髓灰质炎工作的深入开展，由脊髓灰质炎病毒引起的肝病例越来越少，而由其它肠道病毒引起的麻痹病例所占比例越来越大。Ｓ．ｋｏｉｋｅ教授建立了一种Ｌ＿α细胞，该细胞株仅对脊髓灰质炎病毒敏感，而其它肠道病毒不能在其中生长。我们用Ｌ＿α细胞对脊髓灰质炎和其它肠道病毒的分离鉴定做了一些试验研究，显示Ｌ＿α细胞对脊髓灰质炎病毒具有较强的特异性和敏感性。
In the global polio eradication process, laboratories should test a large number of specimens. Due to the differences in the sensitivity of the virus strains to the cells, WHO recommends the use of RD and Hep-2 cell lines for virus isolation and identification. Both of these cells are not only sensitive to poliovirus but also susceptible to other enteroviruses, In particular, some paralytic enterovirus is also sensitive. With the development of poliomyelitis eradication efforts, there are fewer and fewer cases of liver diseases caused by poliovirus, and an increasing proportion of cases of paralysis caused by other enteroviruses. S. Professor Koike established a L_α cell that is only sensitive to poliovirus, while other enteroviruses can not grow in it. We did some experiments on the isolation and identification of polio and other enteroviruses using L_α cells, which shows that L_α cells have strong specificity and sensitivity to poliovirus.