异搏停等钙离子拮抗剂有益于血管痉挛性和劳累性心绞痛的治疗.本文通过单盲和双盲随机交叉研究,估价异搏停治疗劳累性心绞痛的效应及最适当的剂量,并探讨其有益作用的机制.方法:26例男性患者,平均年龄55岁(30～72岁).心绞痛发作次数每周5次以上,平板运动试验均示ST段水平型或下斜型压低1毫米以上并至少持续到J点后80毫秒.在研究前48小时减量并停用对心脏有作用的药物,包括α和β阻滞剂、长效扩血管药物.先进行单盲研究,在服安慰剂2周后每日 Verapamil and other calcium antagonists beneficial vasospasm and exertional angina pectoris treatment.This study by single-blind and double-blind randomized crossover study, evaluation of verapamil for the treatment of exertional angina pectoris effect and the most appropriate dose, and to explore its 26 cases of male patients, the average age of 55 years (30 to 72 years) .The number of angina attacks more than 5 times per week, treadmill exercise test showed that the ST segment horizontal type or down ramp down more than 1 mm and At least 80 milliseconds after point J. Drugs that have an effect on the heart, including alpha and beta blockers, and long-lasting vasodilator drugs, are de-rated and discontinued 48 hours prior to study. A single-blind study was performed first in placebo Daily after 2 weeks