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为了解胎盘血管疾病中引发内皮细胞损伤及功能不良的机制推测脐带胎盘循环血管疾病可能是由于局部释放的某些因子诱导内皮细胞凋亡、损伤从而影响胎儿循环,将人脐静脉内皮细胞分离并培养,暴露于3组不同的胎儿血浆中:正常妊娠32例;脐动脉多普勒检查异常被诊断为脐带胎盘血管疾病38例(其中非先兆子痫21例,先兆于痫17例)及脐动脉多普勒检查正常而临床诊断为先兆子痫者16例。
To understand the pathogenesis of endothelial cell injury and dysfunction in placental vascular disease, it is hypothesized that umbilical cord placental vascular disease may be due to local release of certain factors induce endothelial cell apoptosis, thus affecting fetal circulation, human umbilical vein endothelial cells were isolated Were exposed to 3 different groups of fetal plasma: 32 cases of normal pregnancy; umbilical artery Doppler abnormalities were diagnosed as umbilical cord placental vascular disease in 38 cases (including non-preeclampsia in 21 cases, pre-eclampsia in 17 cases) and navel Arterial Doppler examination of normal and clinical diagnosis of preeclampsia in 16 cases.