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1.本实验选用听觉灵敏、平衡良好、体重在220—300克健康雄性豚鼠48只作慢性实验(实验25只、对照23只),8只雄性大鼠作急性实验(对照、实验各半)。慢性实验者每日一次肌肉内注射链霉素(硫酸盐),剂量为400毫克/公斤加葡萄糖酸钙,200毫克/公斤,100毫克/公斤。急性组一次肌肉内注射600毫克/公斤链霉素。 2.100毫克/公斤剂量者,连续注射任达一个月机能试验和组织化学检查均未见明显变化。400毫克/公斤+Ca及200毫克/公斤剂量者,实验动物平均在2个月左右眼震丧失,听力迟钝。但也有个别动物短在22天,长达158天才出现中毒症状者。 3.本实验对动物的桥脑和延脑进行了组织化学观察,结果表明,慢性中毒豚鼠耳蜗神经腹侧终核、前庭神经外侧终核、三叉神经起核内嫌色性细胞(即本实验中的Ⅲ型细胞)增多。SH基、蛋白质结合的组氨酸、酪氨酸、色氨酸、PAS反应、琥珀酸脱氢酶反应普遍减弱。碱性和酸性磷酸酶活性未见明显变化。 4.对急性和部分慢性中毒动物肋间肌运动终板乙酰胆碱酯酶进行了组织化学检查。急性中毒动物乙酰胆碱酯酶活性减弱,慢性中毒动物者未见明显变化。 5.实验证明:葡萄糖酸钙有解除动物的急性中毒和提高对链霉素耐受剂量的作用。 6.作者认为链霉素对中枢神经系的毒性作用是普遍的。本文对于一些结果进行了讨论。
1. The experiment selected auditory sense, a good balance of weight in 220-300 grams of healthy male guinea pigs 48 for chronic experimental (25 experiments, control 23), 8 male rats for acute experimental (control, experimental half) . Chronic subjects received daily intramuscular streptomycin (sulphate) at a dose of 400 mg / kg plus calcium gluconate, 200 mg / kg, 100 mg / kg. Acute intramuscular injection of 600 mg / kg streptomycin. 2.100 mg / kg dose, up to a month of continuous injection of functional tests and histochemical examination showed no significant change. 400 mg / kg + Ca and 200 mg / kg dose, the experimental animals in about 2 months, nystagmus, hearing loss. But there are also some animals in 22 days short, up to 158 days before symptoms of poisoning. In this experiment, the pontine and extensor of the animal were observed histochemically. The results showed that in the chronic poisoning guinea pig cochlear nerve, the ventral terminal nucleus, the vestibular nucleus, the trigeminal nucleus, In the type III cells) increased. SH group, protein-bound histidine, tyrosine, tryptophan, PAS reaction, succinate dehydrogenase reaction generally weakened. Alkaline and acid phosphatase activity no significant change. Acute and part of chronic poisoning animal intercostal motor end plate acetylcholinesterase histochemical examination. Acute poisoning animals acetylcholinesterase activity weakened, no significant changes in chronic poisoning animals. 5. Experiments show that: calcium gluconate have the lifting of animal acute poisoning and improve the dose of streptomycin. 6. The authors believe that the toxic effects of streptomycin on the central nervous system are common. This article discusses some of the results.