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目的:探讨依那普利联合氯沙坦治疗老年肾性高血压的效果。方法:选取2008年2月～2011年10月我院收治的肾性高血压患者70例,按随机数字表法分为观察组和对照组,每组35例。对照组给予依那普利20mg,每天2次;观察组给予依那普利10mg,每天2次;氯沙坦50mg,每天1次。观察两组血压、肾功能指标变化及不良反应。结果:观察组总有效率为95.0%(38/35),对照组为75.0%(30/35),差异有统计学意义(P<0.05);治疗后两组血压(DBP、SBP)和肾功能(SCr、BUN、mAlb)指标均明显改善(P<0.05),观察组较对照组改善更为明显(P<0.05);观察组不良反应发生为17.14%(6/35),对照组为14.29%(5/35),差异无统计学意义(P>0.05)。结论:依那普利联合氯沙坦治疗老年肾性高血压能更有效改善血压和肾功能,安全性高。
Objective: To investigate the effect of enalapril combined with losartan on senile renal hypertension. Methods: Seventy patients with renal hypertension admitted from February 2008 to October 2011 in our hospital were divided into observation group and control group according to random number table method, with 35 cases in each group. The control group was given enalapril 20mg twice daily. The observation group was given enalapril 10mg twice daily and losartan 50mg once daily. Blood pressure, changes of renal function and adverse reactions were observed. Results: The total effective rate was 95.0% (38/35) in the observation group and 75.0% (30/35) in the control group, with statistical significance (P <0.05). After treatment, the blood pressure (DBP, SBP) (SCr, BUN and mAlb) were significantly improved (P <0.05), and the observation group was more improved than the control group (P <0.05). The incidence of adverse reactions in the observation group was 17.14% (6/35) 14.29% (5/35), the difference was not statistically significant (P> 0.05). Conclusion: Enalapril combined with losartan in the treatment of senile renal hypertension can effectively improve blood pressure and renal function, with high safety.