采用氨基酸自动分析仪检测大鼠脑组织中谷氨酸(Glu)、门冬氨酸(Asp)、牛磺酸(Tau)、甘氨酸(Gly)及丙氨酸(Ala)含量在静脉注入脂多糖(LPS 16mg/kg)造成内毒素休克后1h、3h、6h等时点的动态变化,并同时测定了血压、死亡率、脑系数、脑组织钙含量的变化。结果发现,病理组动物血压呈明显的3个时相变化,5min内迅速下降,30min稍有回升,随后逐渐下降,至3h时,血压呈不可逆下降,下降值与对照组相比,有明显差异 Amino acid analyzer was used to detect the contents of Glu, Asp, Tau, Gly and Ala in rat brain tissue after intravenous injection of lipopolysaccharide LPS 16mg / kg) caused endotoxin shock at 1h, 3h, 6h and other time points of the dynamic changes, and measured blood pressure, mortality, brain coefficient, changes in brain calcium content. The results showed that the blood pressure of the pathological group showed obvious three time-phase changes, dropping rapidly within 5 minutes and slightly increasing after 30 minutes, then gradually decreasing. At 3 hours, the blood pressure showed an irreversible decline, with a significant difference compared with the control group