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(一) 小白鼠腹腔注射一次BAL-glucoside及二巯基丁二酸鈉之LD_(50)分别為5660及2730毫克/千克。 (二) 小鼠腹腔注射吐酒石後立即皮下注射BAL、BAL-glucoside或二巯基丁二酸鈉均能明顯地減低吐酒石的毒性。BAL(40毫克/千克)、BAL-glucoside(2500毫克/千克)及二巯基丁二酸鈉(1500毫克/千克)分别提高吐酒石的LD_(50)從31至52、85及491毫克/千克。其中二巯基丁二酸鈉的解毒效果遠比以往文獻報告之任何解毒劑為佳。 (三) 家兔靜脈注射吐酒石致死量(20毫克/千克)後8小時内注射BAL、BAL-glucoside或二巯基丁二酸鈉,能保護家兔不死,或延長其生存時間。 (四) BAL,BAL-glucoside及二巯基丁二酸鈉均减低吐酒石治療小鼠日本血吸蟲病的療效。其中以二巯基丁二酸鈉的作用最為明顯,能使吐酒石完全失效。
(1) The LD_ (50) of mice once intraperitoneal injection of BAL-glucoside and sodium dimercaptosuccinate were 5660 and 2730 mg / kg, respectively. (B) Immediately after intraperitoneal injection of toadstool into BALB / c mice, BAL, BAL-glucoside, or sodium dimercaptosuccinate were administered to mice in a dose-dependent manner. BAL (40 mg / kg), BAL-glucoside (2500 mg / kg), and sodium dimercaptosuccinate (1500 mg / kg) increased the LD50 of spit tartar from 31 to 52, 85 and 491 mg / kilogram. Sodium dimercaptosuccinate detoxification effect is far better than any antidote reported in the literature. (C) injection of intravenous injection of tartar rabbit intravenous injection (8 mg / kg) within 8 hours after injection of BAL, BAL-glucoside or sodium dimercaptosuccinate can protect rabbits, or extend their survival time. (D) BAL, BAL-glucoside and sodium dimercaptosuccinate both reduce the efficacy of toadstool treatment of Schistosoma japonicum in mice. One of the most obvious role of sodium dimercaptosuccinate, can make vomit stone completely invalid.