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1986年1月～1987年1月间,我们对临床和肝组织学证实的、HBsAg 阳性的慢性活动性肝炎(CAH)70例进行了IgA 型抗-HBc 的临床观察。70例中轻型27例,中型26例、重型4例及CAH 伴肝硬化13例。全部病例于入院时和入院后1、2、3、4月分别取血清检测IgA 型抗-HBc(ElisA)和IgM 型抗-HBc(ElisA)以及HBV 有关血清学标记(HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc、~(32)PHBV-DNA斑点杂交)。每7～10天复查肝功能,并以无症状HBsAg 携带者47例和正常人(献血员)34例作为对照,观察了血清IgA 型抗-HBc 的动态变化。结果:70例中血清IgA 型抗-HBc 检出率为97.1%(68/70),其S/N值(<2.1为正常)CAH轻型为3.32±0.94,CAH 中型3.34±1.01,CAH 重型和CAH 伴肝硬化者为3.95±0.72;而无症状HBsAg 携带者IgA 型抗-HBc 检出率为17.0%(8/47),S/N 值为1.54±1.03;正常
From January 1986 to January 1987, we performed clinical observations of IgA anti-HBc in 70 patients with clinically and histologically confirmed HBsAg-positive chronic active hepatitis (CAH). 70 cases of mild in 27 cases, 26 cases of medium, 4 cases of heavy and CAH with cirrhosis in 13 cases. Serum samples were collected for detection of IgA anti-HBc (ElisA) and IgM anti-HBc (ElisA) and HBV serological markers (HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc, ~ (32) PHBV-DNA dot blot). The liver function was reviewed every 7-10 days, and 47 cases of asymptomatic HBsAg carriers and 34 normal persons (blood donors) were used as controls to observe the dynamic changes of serum IgA anti-HBc. Results: The detection rate of serum IgA anti-HBc in 70 cases was 97.1% (68/70). The S / N value (<2.1 was normal) was 3.32 ± 0.94 for CAH, 3.34 ± 1.01 for CAH medium, The detection rate of IgA anti-HBc in asymptomatic HBsAg carriers was 17.0% (8/47) and the S / N value was 1.54 ± 1.03. The normal