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目的观察续命降糖方联合前列腺素E1(PGE1)治疗糖尿病足对ET、CGRP平衡的影响。方法将40例糖尿病足病人分成治疗组和对照组,治疗组(n=20)采用基础治疗+口服续命降糖方+静滴前列腺素E1并与对照组(n=20)采用基础治疗+静脉滴注PGE1进行比较。观察治疗前后糖尿病足溃疡愈合的疗效判定及治疗前后内皮素(ET)、降钙素基因相关肽(CGRP)的测定。结果治疗组与对照组疗效比较,治疗组总有效率达90.0%,对照组为60.0%,两组比较差异有显著(P<0.01);对照组治疗前后ET、CGRP水平有明显差异(P<0.05),但治疗组治疗前后ET、CGRP水平差异更显著(P<0.01)。结论糖尿病足患者(DF)ET水平升高、CGRP水平下降;续命降糖方联合PGE1治疗后ET水平下降、CGRP水平回升显著;续命降糖方联合PGE1比单纯PGE1治疗糖尿病足疗效更显著。
Objective To observe the effect of decoction of reducing blood sugar and prostaglandin E1 (PGE1) on the balance of ET and CGRP in diabetic foot. Methods 40 cases of diabetic foot patients were divided into treatment group and control group. The treatment group (n = 20) was treated with basic therapy + oral administration of sedative and hypoglycemic prescription + intravenous prostaglandin E1 and the control group (n = 20) Intravenous infusion of PGE1 for comparison. The curative effect of diabetic foot ulcer healing before and after treatment and the determination of endothelin (ET) and calcitonin gene related peptide (CGRP) before and after treatment were observed. Results Compared with the control group, the total effective rate was 90.0% in the treatment group and 60.0% in the control group, with significant difference between the two groups (P <0.01); ET and CGRP levels in the control group were significantly different before and after treatment (P < 0.05), but the treatment group before and after treatment ET, CGRP levels more significant difference (P <0.01). Conclusion The level of ET and the level of CGRP in patients with diabetic foot increased (DF), the level of ET decreased and the level of CGRP rose significantly in the combination of decoction and hypoglycemic agents combined with PGE1. The effect of decoction and hypoglycemic combination with PGE1 was more effective than that of PGE1 alone .