论文部分内容阅读
16-α-羟基雌酮和雌三醇是雌二醇碳16-α位羟化的产物。作者发现SLE患者血浆及早期SLE患者尿中,16-α-羟基雌酮均明显升高,且无性别差异。雌三醇则相反,仅在女性和同时患Klinefelter病(一种女性化综合征)的SLE男性中才升高。作者认为检测16-α-羟基雌酮是研究一些疾病如SLE的一个很有用的辅助手段,因此他们建立了特异性放免方法。所选择的血浆来自正常自愿者、SLE患者及其它的结缔组织病患者。SLE患者均符合ARA的诊断标准,同时不合并甲状腺及肝脏疾病,未用或仅用少量肾上腺皮质激素治疗。取样时间在月经周期的卵泡中期,检测结果发现SLE患者的16-α-羟基雌酮明显地比正常对照组及其它结缔组织病高。根据临床和血清学,把SLE分为活动性和非活动性两组。活动性的SLE与正常对照及其它结
16-α-Hydroxyestrone and estriol are the hydroxylated products of the 16-alpha-estradiol carbon. The authors found that urine and 16-α-hydroxyestrone in patients with SLE and early SLE were significantly elevated, and no gender differences. In contrast, estriol increased only in women and in SLE men with Klinefelter’s disease, a feminized syndrome. The authors consider detecting 16-α-hydroxyestrone as a useful adjunct to studying a number of diseases such as SLE and therefore they have established specific methods for radiosurgery. Selected plasma from normal volunteers, SLE patients and other patients with connective tissue disease. SLE patients are in line with the diagnostic criteria of ARA, without thyroid and liver disease, unused or only a small amount of adrenal cortex hormones. Sampling time in the menstrual cycle in the follicular metaphase, the test results found that SLE patients with 16-α-hydroxy estrone significantly higher than the normal control group and other connective tissue disease. According to clinical and serological, SLE is divided into active and inactive groups. Active SLE with normal controls and other knots