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研究发现,肿瘤与血液促凝作用的增强相关。一般认为促凝系统(血纤维蛋白沉淀)与血纤维蛋白溶酶系统(酶降解血纤维蛋白)之间存在一种平衡。然而在恶性肿瘤(如卵巢癌)中,这种平衡被打破,导致促凝或高凝结作用的异常活性。有证据表明,这种平衡通路的多变性是由于肿瘤的恶性特征所致(如增殖浸润和转移)。作者研究的目的是明确卵巢癌中肿瘤细胞与促凝作用(原始前体促凝剂)和纤维蛋白形成尿激酶型原始血纤维蛋白溶酶原活化因子)(μ-
The study found that tumors are associated with increased blood procoagulant effects. It is generally believed that there is a balance between the procoagulant system (fibrin deposition) and the plasmin system (enzyme degrading fibrin). However, in malignant tumors, such as ovarian cancer, this balance is broken, resulting in aberrant activity of coagulation or hypercoagulation. Evidence suggests that the variability of this balance is due to the malignant characteristics of tumors (eg, proliferative infiltration and metastasis). The aim of the authors’ study was to elucidate the role of tumor cells in procoagulant (procoagulant precursor) and fibrin in the formation of urokinase-type prothrombin activators of ovarian cancer (μ-