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目的 研究术前溴隐停治疗对女性泌乳素腺瘤患者经蝶手术疗效的影响。方法 采用病例对照研究方法 ,选择 6 0例术前曾服用溴隐停治疗的女性泌乳素腺瘤经蝶手术患者作为研究对象(术前服药组 ) ,根据临床特点 ,为每名术前服药组患者选择一名术前未服药的女性经蝶手术患者作为对照。两组患者的年龄、病程、治疗前泌乳素水平、肿瘤大小及是否浸润均无统计学差异。结果 术前服药组患者肿瘤质地较韧硬的比例明显高于对照组 ,两组患者肿瘤全切除率基本相同。术前服药组泌乳素由术前 2 71 2 3± 3 2 9ng/ml降至 37 0 1± 7 4 8ng/ml (P <0 0 0 1) ,对照组泌乳素由 2 6 0 0 7±3 15ng/ml降至 34 2 1± 5 90ng/ml (P <0 0 0 1) ,两组患者术后泌乳素值无显著差异 (P =0 6 9)。两组患者手术治愈率亦无明显统计学差异 (术前服药组为 5 1 6 7% ,对照组为 5 8 33% ,P =0 5 )。结论术前溴隐停治疗对女性泌乳素腺瘤经蝶显微外科手术的疗效无明显影响。
Objective To study the effect of preoperative bromine inactivation on the efficacy of transsphenoidal surgery in female prolactinomas. Methods A case-control study was conducted in 60 female patients with transsphenoidal surgery of prolactinoma who had been treated with bromocriptine before surgery (preoperative medication group). According to the clinical characteristics, The patient selected a non-preoperative female transsphenoidal surgery as a control. Two groups of patients age, duration, prolactin levels before treatment, tumor size and whether infiltration were not statistically different. Results Before operation, the tumors in the patients with tumors were tougher than those in the control group. The resection rates of tumors in both groups were basically the same. The preoperative serum prolactin decreased from 2 71 2 3 ± 3 29ng / ml preoperatively to 37 0 1 ± 7 48ng / ml (P 0 01), while the prolactin in the control group decreased from 26 0 0 7 ± 3 15 ng / ml to 34 2 1 ± 5 90 ng / ml (P <0 0 01). There was no significant difference in postoperative prolactin values between the two groups (P = 0.069). There was no significant difference in the surgical cure rate between the two groups (51.67% in the preoperative group and 58.3% in the control group, P = 0 5). Conclusion Preoperative bromine block treatment of female prolactinoma had no significant effect of microsurgical treatment.