论文部分内容阅读
目的探讨肝细胞性肝癌患者外周血自然杀伤细胞（ＮＫ）活性与乙型肝炎表面抗原（ＨＢｓＡｇ）、甲胎蛋白（ＡＦＰ）、肿瘤大小、转移及黄疸的关系。方法应用５－１２５Ｉ－２′－脱氧尿嘧啶核苷（１２５Ｉ－ＵｄＲ）释放法分别对５１例肝癌患者和４８例正常人进行ＮＫ活性测定。结果肝癌患者外周血ＮＫ活性明显低下（３８．３０％±１７．０３％，Ｐ＜０．００１），与血清中ＨＢｓＡｇ无关，而与血清中ＡＦＰ呈负相关关系（ｒ＝－０．４５６，Ｐ＜０．０１），且随着患者肿瘤的增大和转移及出现黄疸ＮＫ活性进一步下降。结论ＮＫ活性可作为一种免疫监视指标，对判断肝癌的疗效和预后有一定的临床指导意义
Objective To investigate the relationship between peripheral blood natural killer cell (NK) activity and hepatitis B surface antigen (HBsAg), alpha-fetoprotein (AFP), tumor size, metastasis, and jaundice in patients with hepatocellular carcinoma. Methods The NK activity was measured in 51 patients with hepatocellular carcinoma and 48 normal controls using 5-125I-2′-deoxyuridine (125I-UdR) release method. Results The peripheral blood NK activity was significantly lower in HCC patients (38.30%±17.03%, P<0.001), but not in serum HBsAg, but negatively correlated with serum AFP (r=-0.456, P<0.01), and the NK activity of jaundice decreased further with the increase of tumors and metastasis of patients. Conclusion The NK activity can be used as an immune surveillance indicator, which has certain clinical significance for judging the curative effect and prognosis of liver cancer.