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一、概况:环已烷氨基磺酸钠Sodium cyclohexyl Sulfamate。商品名甜蜜素、浓缩糖。1937年美国进行研究,1950年做为食品甜味料,50～60年代已成为国际上应用的一种人工合成甜味剂,1969年10月美国提出有致畸作用,美、日等国先后被禁用。1978年FAO/WHO/JECFA24次会议审查一系列毒理试验报告,否定致畸作用,制订ADI 0～4mg/kg/日,1982年FAO/WHO/JECFA又进行评价,制订ADI 0～11mg/kg/日,据了解今年4月美国食品及药品管理局(FDA)批准予以使用。目前丹麦、瑞典、芬兰、加拿大、印尼、巴西等国及台湾地区亦允许使用,台湾年产量3,000T、印尼5,000T、巴西2,000T。
First, an overview: sodium cyclohexyl sulfamate Sodium cyclohexyl Sulfamate. Product name cyclamate, concentrated sugar. In 1937, the United States conducted research. As a food sweetener in 1950, it became an internationally used synthetic sweetener in the 1950s and 1960s. In October 1969, the United States made a teratogenic effect. The United States, Japan and other countries successively Disabled In 1978, the 24th meeting of FAO / WHO / JECFA reviewed a series of toxicological test reports, denying teratogenicity and establishing 0-4 mg / kg / day of ADI. In 1982, FAO / WHO / JECFA further evaluated and formulated ADI 0-11 mg / kg / Day, it is understood that in April this year the US Food and Drug Administration (FDA) approved the use. At present, Denmark, Sweden, Finland, Canada, Indonesia, Brazil and other countries in Taiwan and Taiwan are also allowed to use Taiwan’s annual output 3,000T, 5,000T Indonesia and 2,000T Brazil.