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Two different strains of human herpes simplex virus type 2(HHS V-2)and /or murine leukemia virus(MLV)were inoculated into newborn mice.In mice of mixed infection with MLV plus HHSV-2(333) or MLV plus HHSV-2(Wu)incidences of leukemia were r esp ectively 79.16% and 75.00%,and in those inoculated with MLV alone were 41.02% and 44.74% in the experiment for 3 months.The differences of incidences between the two conditions were highly significant(p<0.01).On the contrary,no leukemia w as detected in mice that were inoculated with HHSV-2(333) or HHSV-2(Wu)alone a nd in co ntrols.Leukemia developing time of mice infected with two viruses was earlier th an with MLV alone.It is obvious that the induction of murine leukemia resulted f rom infection of MLV and was independent of HHSV-2(333) and HHSV-2(Wu).Both ri s en incidences and shortened latencies of murine leukemia were in close relations hip with infection of HHSV-2(333) and HHSV-2(Wu).
Two different strains of human herpes simplex virus type 2(HHS V-2)and /or murine leukemia virus(MLV)were inoculated into newborn mice.In mice of mixed infection with MLV plus HHSV-2(333) or MLV plus HHSV- 2(Wu)incidences of leukemia were r esp ectively 79.16% and 75.00%,and in those inoculated with MLV alone were 41.02% and 44.74% in the experiment for 3 months.The differences of incidences between the two conditions were highly significant(p <0.01).On the contrary, no leukemia w as detected in mice that were inoculated with HHSV-2(333) or HHSV-2(Wu)alone a nd in co ntrols.Leukemia developing time of mice infected with two viruses . Th an with MLV alone.It is obvious that the induction of murine leukemia resulting f rom infection of MLV and was independent of HHSV-2(333) and HHSV-2(Wu).Both ri s en incidences and shortened latencies of murine leukemia Were in close relations hip with infection of HHSV-2(333) and HHSV-2(Wu).