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目的探讨黄芩黄酮与维生素E单独与联合应用对染尘小鼠肺损伤过程中SOD活性、MDA、LDH以及Hyp含量的影响。方法采用气管注入法给予二氧化硅混悬液(SiO2)建立染尘鼠模型。建模1周后按照2×2析因设计将实验动物分为模型对照组A,黄芩黄酮干预组B,维生素E干预组C,黄芩黄酮与维生素E联合干预组D,并设正常对照组N。给药2周后分别测定各组的SOD活性、MDA、LDH以及Hyp的含量。结果与模型对照组比较,黄芩黄酮组、维生素E组、黄芩黄酮与维生素E联合组均能提高SOD活性,可有效减少MDA的产生(P<0.05),黄芩黄酮与维生素E联合组的效果较单独应用效果明显;黄酮黄芩与维生素E联合能明显减少Hyp、LDH的含量及肺体重指数(P<0.05)。结论黄芩黄酮与维生素E有交互作用,能提高小鼠SOD的活性,减少LDH、脂质过氧化反应物以及Hyp的生成,对肺损伤有更好的保护作用。
Objective To investigate the effects of skullcap flavonoids and vitamin E alone or in combination on SOD activity, MDA, LDH and Hyp contents during lung injury in mice exposed to dust. Methods The model of stained mice was established by tracheal injection of silicon dioxide suspension (SiO2). One week after modeling, the experimental animals were divided into model control group A, Scutellaria flavone intervention group B, vitamin E intervention group C, skullcap flavonoids and vitamin E intervention group D according to 2 × 2 factorial design, and normal control group N . After 2 weeks of administration, the activity of SOD, MDA, LDH and Hyp in each group were determined. Results Compared with the model control group, skullcap flavonoids, vitamin E group, skullcap flavonoids and vitamin E group can improve the activity of SOD and reduce the production of MDA (P <0.05). The effect of skullcap flavonoids and vitamin E combination group The effect of application alone was obvious. The combination of flavonoid skullcap and vitamin E could obviously reduce the content of Hyp, LDH and the body mass index (P <0.05). Conclusion Scutellaria flavonoids interact with vitamin E, which can increase the activity of SOD in mice and reduce the production of LDH, lipid peroxidation and Hyp, and have a better protective effect on lung injury.