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急、慢性酒精中毒可引起肾小管功能减退,亦可直接或间接损害肾小球及肾间质,最终导致肾功能衰竭。酒精性肾损害,突出地表现为肾小管功能减退。Labib等报告40%病人有尿中α_1微球蛋白和视网膜结合蛋白的排量增多,也常见β_2微球蛋白增加,前者可作为判定肾小管功能减退的一个可靠指标。此外,不少作者发现,与肾损害有关的酶,如N—乙酰—β—葡萄糖胺酶显著增高,也可作为肾小管损害的佐证之一。慢性酒精中毒患者约有1/3～1/4病人有钠、
Acute and chronic alcoholism can cause tubular dysfunction, can also directly or indirectly damage the glomerular and renal interstitium, eventually leading to renal failure. Alcoholic kidney damage, prominently manifested as tubular dysfunction. Labib and other reports of 40% of patients with urinary α 1 microglobulin and retinal binding protein increased displacement, but also common β 2 microglobulin increased, the former can be used as a reliable indicator of renal tubular dysfunction. In addition, many authors have found that enzymes associated with renal impairment, such as N-acetyl-β-glucosaminidase, are significantly elevated and may also serve as a corollary to tubular damage. About 1/3 to 1/4 of patients with chronic alcoholism have sodium,