论文部分内容阅读
微粒体药物代谢酶在药物和毒物代谢中起重要作用,成为目前药理学和毒理学共同关注的一个研究方面。研究毒物对微粒体酶的影响,对于阐明毒物的作用抗理以及探索防治措施都有重要意义。本实验应用佐藤氏气相色谱法,测定了短期多次给予实验小鼠四种作为高分子聚合物稳定剂使用的受阻酚类抗氧剂后不同时间的肝微粒体甲苯代谢率,并进一步探讨了以微粒体甲苯代谢率
Microsomal drug metabolizing enzymes play an important role in the metabolism of drugs and toxins and become a research area that is currently a focus of common concern in pharmacology and toxicology. Studying the effect of poisons on microsomal enzymes is of great significance for elucidating the toxicological effects and exploring the preventive measures. In this experiment, Saturn’s gas chromatography was used to determine the toluene metabolism rate of liver microsomes at different time points after being treated with four different kinds of hindered phenolic antioxidants used as polymer stabilizers in short-term and repeated experiments To microsomal toluene metabolic rate