To the Editor:We appreciate the attentive and interesting article Efficacy of weight adjusted bone mineral content in osteoporosis diagnosis in Chinese female population written by Liu et al[11] The authors have nicely shown bones are three dimensional tissues,only volumetric bone mineral density (vBMD) can be regarded as completely standardized,since the areal bone mineral density (aBMD) is two-dimensional and could result in missed diagnosis in subjects with large bones and misdiagnosis in those with small bones.In addition,although vBMD has undeniable advantages,the most sophisticated dual-energy X-ray absorptiometry (DXA) instrument is not able to measure the bone volume in vivo.Therefore,they attempted to use weight-standardized bone mineral content (wBMC) to replace vBMD for osteoporosis diagnosis,such missed diagnosis or misdiagnosis may be avoided.