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为证实诸氏复骨丸对激素性股骨头缺血性坏死组织学变化的影响。采用贺氏造模法制成大白兔激素性早期股骨头缺血性坏死模型，分别从 Ｘ 线摄片、四环素标记、病理学观察、电镜观察等方面研究诸氏复骨丸对骨骼生长代谢的促进作用。结果显示用药后预防组和治疗组能够恢复骨细胞分泌胶原的合成作用，减少骨细胞的死亡和骨量的丢失。并且从超微结构上提示细胞形态及成份的变化。其中，预防组的效果最优。说明诸氏复骨丸对骨细胞胶原的合成和减少骨细胞的死亡及骨量的丢失有一定促进作用。
To confirm the effect of Zhushi Fugu Wan on the histological changes of steroid-induced avascular necrosis of the femoral head. The model of early femoral head necrosis of the femoral head was made by using He’s method. The effects of Zhushi Fugu Pills on the growth and metabolism of bones were studied from X-ray and tetracycline markers, pathological observation and electron microscopy. effect. The results showed that the prophylactic and therapeutic groups after administration could restore the synthesis of collagen secreted by bone cells and reduce the death of bone cells and the loss of bone mass. And from the ultrastructure prompted changes in cell morphology and composition. Among them, the preventive group has the best results. It was shown that Zhushi Fugu Pills promoted the synthesis of collagen in bone cells and reduced the death of bone cells and the loss of bone mass.