【摘 要】
:
NF-κB, a family of related transcription factors, has been a focus of intense scientific research during the past decade.Multiple stimuli, both extracellular a
【机 构】
:
Division of Hematology-Oncology, Department of Medicine, Harold Simmons Cancer Center, University of
论文部分内容阅读
NF-κB, a family of related transcription factors, has been a focus of intense scientific research during the past decade.Multiple stimuli, both extracellular and intracellular, lead to its activation.The NF-κB pathway regulates expression of a diverse array of genes involved in different biological processes.Various pathological states are characterized by the dysregulated NF-κB pathway.Recently,NF-κB activation has been connected with multiple aspects of oncogenesis and serves as an important mechanism to regulate cell survival in response to chemotherapy by activating different genes that inhibit apoptosis.Several methods of inhibiting NF-κB activation, such as antisense oligonucleotides, proteosome inhibitors and RNA interference (RNAi) are currently under investigation.RNAi represents a powerful tool to better define the role of specific genes in different signal transduction pathways and has recently been used to define the function of genes that regulate the NF-κB pathway.This review discusses the emerging role of RNAi to dissect the function of regulatory factors in the NF-κB pathway and its potential use as a targeted therapy.
其他文献
在广泛调查旱作粮田作物产量和野外实地观测深层土壤湿度的基础上,应用美国研制的环境政策综合气候模型-WinEPIC,模拟研究了1960~2000年期间黄土高原中部不同降水类型区不同肥
配合力是评价玉米育种材料的重要指标,主要农艺性状的遗传表达特点可为农艺性状的选择提供理论依据。本文以糯玉米自交系S147(CK)及其航空处理诱变系M562、M563、M564、M566、M567、M568、M569为母本,以糯玉米自交系S181(CK)及其航空处理诱变M571、M573、M574、M575、M576作父本,按照NCⅡ不完全双列杂交试验设计,分析航空处理对糯玉米自交系S147、S18
本文讨论福建省水稻土分类。把水稻土分为三个亚类型:渗育性水稻土、潴育性水稻土、潜育性水稻土。土属的划分是以起源土壤中的粘土矿物组合和母质的不同而分为八个属:1、砖
太空环境通过高真空、微重力、强辐射、高能粒子辐射、交变磁场及其它因素的单独或复合作用,影响植物的生长发育,诱发植物体不同水平的突变。这是扩大遗传变异,创造新种质和培育新品种的重要方法之一。 本文研究了航天诱变处理棉花种子,对SP1辐射生物学效应,SP2代的棉花的诱变效应,及部分形态突变体的多态性分析。主要结果如下: (1) 航天诱变处理对棉花生育期的影响。 对三个棉花高世代品系航
病毒病曾是严重影响马铃薯产量及种薯质量的一个世界性难题,因应用茎尖分生组织脱毒技术才得到了较有效的解决.试管马铃薯的生产由于其优异的应用前景而备受国内外科学研究者
In this study,the multi-sensing system based on the tin oxide pH electrode for the ion-determination was presented. With the advantages of the real-time supervi
本文详细分析探讨了建筑智能化系统工程设计中所存在的若干典型问题,并提出一些合理的改进建议。
This article analyzes and discusses in detail some typical problems e
我院是以骨科专业为龙头的三级甲等综合性医院,近年来我院住院病人总数以每年四千人次左右的速度递增,日占有床位数均在四千人以上,随着出院人数的增加,病案库的占地面积需要
Aim: To investigate the protective effect of high density lipoprotein 3 (HDL3) on oxidized low density lipoprotein (ox-LDL)-induced apoptosis in RAW264.7 cells.
AIM: To explore the effect of β-amyloid (Aβ) on metabolism of cytoskeletal protein neurofilament, and search for effective cure to the lesion. METHODS: Wild t