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The IGC 50 (50% inhibitory growth concentration) values of 27 nitrobenzenes were determined for the population growth endpoint of Tetrahymena pyriformis . The toxicity order of the observed compounds was found to be as follows: dinitro compounds>mononitro compounds, dichloronitrobenzenes>monochloronitrobenzenes, meta substituted nitrobenzenes>ortho /para substituted nitrobenzenes(NT, NPh, NAnis) except for the dinitrobenzenes and nitroanilines(DNB, NAn). Quantitative structure activity relationships(QSARs) were developed with the logarithm of the reciprocal of IGC 50 [lg(IGC 50 ) -1 ] in mole liter as dependent variable and six molecular descriptors lg P , 1 X Ⅴ, I, 1K a, ∑σ - and E LUMO as independent variables. Via multiple regression analysis, one best equation was obtained: lg(IGC 50 ) -1 =3.029+0.860∑ σ -+0.341I n=27, r=0.924, r 2=0.854, s=0.265, f=70.44 , Pr> f =0.000 1 The equation was used to estimate IGC 50 for five analogues.
The IGC 50 (50% inhibitory growth concentration) values of 27 nitrobenzenes were determined for the population growth endpoint of Tetrahymena pyriformis. The flawed order of the observed compounds was found to be as follows: dinitro compounds> mononitro compounds, dichloronitrobenzenes> monochloronitrobenzenes, meta (NT, NPh, NAnis) except for the dinitrobenzenes and nitroanilines (DNB, NAn). Quantitative structure activity relationships (QSARs) were developed with the logarithm of the reciprocal of IGC 50 [IG ) -1] in mole liter as dependent variable and six molecular descriptors lg P, 1 X Ⅴ, I, 1K a, Σσ - and E LUMO as independent variables. Via multiple regression analysis, one best equation was obtained: Γ lg (IGC 50) -1 = 3.029 + 0.860Σ σ - + 0.341I n = 27, r = 0.924, r 2 = 0.854, s = 0.265, f = 70.44, Pr> f = The equation was used to estimate IGC 50 for five analogues.