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目的分析全身麻醉患者术后谵妄(PD)与脑损伤相关生物学标记物的关系。方法 90例择期全身麻醉患者,于术前1 d和术后苏醒期采用意识错乱评估法(CAM)量表进行谵妄状态评定,术后发生谵妄的患者为谵妄组(45例),未发生谵妄的患者为非谵妄组(45例)。并分别于术前、苏醒期,抽取血清用酶联免疫吸附法(ELASA)测定S100β、神经无特异性烯醇化酶(NSE)值。结果血清S100β蛋白、NSE值在术后谵妄患者和非谵妄患者间,差异无统计学意义(P>0.05)。结论血清S100β蛋白、NSE与术后谵妄发生无明显相关性。
Objective To analyze the relationship between postoperative delirium (PD) and biological markers related to brain injury in general anesthesia patients. Methods Ninety patients undergoing elective general anesthesia were assessed for delirium status by the Consciousness Assessment (CAM) scale on day 1 before surgery and during postoperative recovery. The delirium group was delirium (n = 45), and no delirium occurred Of the patients were non-delirium group (45 cases). The levels of S100β and neuron specific enolase (NSE) were determined by enzyme linked immunosorbent assay (ELASA) before and during resuscitation. Results There was no significant difference in serum S100β protein and NSE between postoperative delirium patients and non-delirium patients (P> 0.05). Conclusion Serum S100β protein and NSE have no significant correlation with postoperative delirium.