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目的： 比较９９ｍＴｃＮＯＥＴ（ＮＯＥＴ：Ｎ乙氧基Ｎ乙基氨荒酸钠）和２０１Ｔ１ 心肌显像在冠心病（ＣＨＤ） 诊断中作用。方法：ＣＨＤ组：２３ 例，其中冠脉造影１４ 例；对照组：８ 例，其中冠脉造影２ 例。所有对象均进行９９ｍＴｃＮＯＥＴ及２０１Ｔ１ 运动—再分布ＳＰＥＣＴ显像。结果：①运动及再分布显像的心肌节段的放射性摄取一致性分别为２６９／２７９（９６．４％ ， Ｋ ＝ ０．８９ ±０．０６） 和２６０／２７９（９３．２％ ，Ｋ＝０．７９±０．１８） ，一致性极好。②在本研究中，９９ｍＴｃＮＯＥＴ心肌显像诊断ＣＨＤ的敏感性和特异性分别为９１．３％ 、８７．５％ ，而２０１Ｔ１ 分别为８６．９％ 、８７．５ ％ 。９９ｍＴｃＮＯＥＴ和２０１Ｔ１ 显像诊断冠脉病变的敏感性和特异性分别为７１．４％ 、８５．０％ 和７５．０％ 、８５．０％ ，两者比较均无显著性差异。③再分布心肌节段一致性达８０％ 。结论：９９ｍＴｃＮＯＥＴ心肌显像在冠心病上的作用与２０１Ｔ１ 相似；两种显像剂在正常心肌内动力学基本相似，但灌注异常的心肌节段有一定差异，机理不详，可能是两者生物行为不同所致。
Objective: To compare the role of 99mTcNOET (NOET: NethoxyNethyladenosailate) and 201T1 myocardial imaging in the diagnosis of coronary heart disease (CHD). Methods: CHD group: 23 cases, of which 14 cases of coronary angiography; control group: 8 cases, including coronary angiography in 2 cases. All subjects were 99mTc NOET and 201T1 sports - redistribution SPECT imaging. Results: ① The consistency of radioactive uptake of myocardial segments in exercise and redistribution was 269/279 (96.4%, K = 0.89 ± 0.06) and 260/279 (93.2%, K = 0.79 ± 0.18), excellent agreement. ② In this study, the sensitivity and specificity of 99mTcNOET myocardial imaging in diagnosing CHD were 91.3% and 87.5%, respectively, while those of 201T1 were 86.9% and 87.5% respectively. The sensitivity and specificity of 99mTcNOET and 201T1 imaging in the diagnosis of coronary artery lesions were 71.4%, 85.0% and 75.0%, 85.0% respectively. There was no significant difference between the two groups. ③ re-distribution of myocardial segment consistency of 80%. Conclusion: 99mTc NOET myocardial imaging in the role of coronary heart disease and 201T1 similar; two imaging agents in normal myocardial dynamics were similar, but there are some differences in myocardial perfusion abnormalities, the mechanism is unknown, it may be both Biological behavior caused by different.