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[目的]研究幽门螺杆菌(Hp)感染与血清炎症因子及同型半胱氨酸(Hcy)水平的相关性,探讨其临床意义。[方法]~(14)C尿素呼气试验的165例患者,将其分成Hp阳性组(82例)和Hp阴性组(83例),对2组血清中的炎症因子——白细胞介素-18、肿瘤坏死因子-α、高敏C-反应蛋白的水平及Hcy水平进行检测,比较2组患者的差异;并对Hp阳性组中经治疗后Hp转阴者进行治疗前后的以上指标比较。[结果]Hp阳性组患者血清炎症因子及Hcy水平均明显高于Hp阴性组,差异有统计学意义(P<0.05);Hp阳性组中Hp转阴者治疗后血清炎症因子及Hcy水平均明显低于治疗前,差异有统计学意义(P<0.05)。[结论]Hp感染可使血清相关炎症因子升高,进而诱发其他相关性疾病。
[Objective] To investigate the correlation between Helicobacter pylori (Hp) infection and serum inflammatory factors and homocysteine (Hcy) levels and to explore its clinical significance. [Methods] 165 patients with ~ (14) C urea breath test were divided into two groups: Hp positive group (82 cases) and Hp negative group (83 cases). The levels of inflammatory cytokines, interleukin - 18, tumor necrosis factor-α, high-sensitivity C-reactive protein levels and Hcy levels were detected, the difference was compared between the two groups of patients; and Hp positive group in the treatment of Hp after the above treatment compared with the above indicators. [Results] Serum inflammatory factors and Hcy levels in Hp positive group were significantly higher than those in Hp negative group, the difference was statistically significant (P <0.05); serum Hp and Hcy levels in Hp positive group were significantly lower than those in Hp negative group Before treatment, the difference was statistically significant (P <0.05). [Conclusion] Hp infection can increase serum related inflammatory factors and induce other related diseases.