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十二指肠溃疡(DU)的病因学和发病机理虽经多年研究,迄今尚未完全阐明。在诸多因索中,胃酸-胃蛋白酶的消化作用,特别是胃酸分泌失调在DU的发病机理中占首要地位。除植物神经的因素外,许多胃肠激素可以影响胃酸分泌.如具有强大刺激胃酸分泌作用的胃泌素(Gas)和对胃酸分泌、Gas释放以及胃肠运动功能具有抑制作用的生长抑素(SS)等。这些胃肠激素的产生和分泌异常,可能会直接或间接参与消化性溃疡的发病过程。关于胃肠激素在DU发病机理中作用的研究,国内外已有报告,但到目前为止结果迥异,尚未取得一致结论。本文拟就Gas、SS在DU患者血和胃肠粘膜中的含量及其内分泌细胞数量变化等方面作一简述。
Duodenal ulcer (DU) etiology and pathogenesis after years of research, has not yet been fully elucidated. Digestion of gastric acid-pepsin, especially gastric acid secretion, plays a primary role in the pathogenesis of DU in many factors. In addition to autonomic factors, many gastrointestinal hormones can affect gastric acid secretion, such as gastrin (Gas), which has potent gastric acid secretion, and somatostatin, which inhibits gastric acid secretion, gas release, and gastrointestinal motility SS) and so on. Abnormal secretion and secretion of these gut hormones may directly or indirectly participate in the pathogenesis of peptic ulcer. The study on the role of gastrointestinal hormones in the pathogenesis of DU has been reported both at home and abroad, but the results so far are far different and no conclusive conclusions have been reached yet. This article intends to Gas, SS in DU patients with blood and gastrointestinal mucosal content and changes in the number of endocrine cells made a brief review.