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目的探讨多种尿微量蛋白联合检测对系统性红斑狼疮(SLE)患者早期肾损害的诊断意义。方法采用免疫比浊法联合检测81例常规肾功能检查阴性的SLE患者8种尿微量蛋白含量,进行半定量、定性分析,并与29名健康者比较。结果 SLE患者IgGU、kapU、lamU、β2-MG、mALBU、α1-MU、TrfU 7种尿微量蛋白阳性率及含量均明显高于正常对照者,差异有统计学意义(P<0.05),α2-MU阳性率及含量与对照组相比,差异无统计学意义(P>0.05),联合检测8种尿微量蛋白较单项检测阳性率明显升高。结论联合检测8种尿微量蛋白含量对SLE患者肾损害进行早期诊断具有积极意义。
Objective To investigate the diagnostic value of combined detection of multiple urinary microalbuminuria on early renal damage in patients with systemic lupus erythematosus (SLE). Methods Eight kinds of urinary microalbuminuria in 81 patients with SLE with routine renal function test were detected by immunoturbidimetry and semiquantitative and qualitative analysis was performed and compared with 29 healthy controls. Results The positive rates and contents of urinary microalbumin in IgGU, kapU, lamU, β2-MG, mALBU, α1-MU and TrfU in SLE patients were significantly higher than those in normal controls (P <0.05) There was no significant difference in the positive rate and content of MU between the control group and the control group (P> 0.05). The positive rate of 8 microalbuminuria detected by combined detection was significantly higher than that of the single test. Conclusion The combined detection of eight microalbuminuria is of positive significance for the early diagnosis of renal damage in patients with SLE.