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心肌缺血可引起左室舒张和收缩功能异常,且舒张功能异常可能较早出现。舒张早期的心肌松弛是主动的,能量依赖性过程,由肌浆网回收钙离子而起始。本文研究已使用最大耐受量β-阻滞剂和硝酸酯后再加用钙拮抗剂硝苯啶对冠心病患者静息时和运动时心脏舒张功能的影响。方法:14例慢性稳定型心绞痛病人使用最大耐受量β-阻滞剂和长效硝酸甘油酯后仍有劳力型心绞痛,其中男12例,女2例,平均年龄61(47～71)岁。调节β-阻滞剂剂量使静息时心率<60次/分,硝酸酯使收缩压≤115mmHg。分别给予普萘洛尔(心得安)6例(平均140mg/day),美托洛尔(美多心安)5例(平均140mg/day),纳多洛尔(心得乐)2例及
Myocardial ischemia can cause left ventricular diastolic and systolic dysfunction, and diastolic dysfunction may occur earlier. Early diastolic myocardial relaxation is an active, energy-dependent process that begins with the recovery of calcium ions by the sarcoplasmic reticulum. This study investigated the effects of maximum tolerated beta-blockers and nitrates plus nifedipine on cardiac diastolic function at rest and during exercise in patients with coronary heart disease. Methods: Fourteen patients with chronic stable angina who had maximal tolerance to beta-blockers and long-acting nitroglycerin still had exertional angina pectoris, including 12 males and 2 females, with an average age of 61 (47-71) years . Β-blockers adjust the dose to rest at heart rate <60 beats / min, nitrate systolic blood pressure ≤ 115mmHg. Propranolol (propranolol) were given in 6 cases (mean 140mg / day), Metoprolol (Metoprolol) in 5 cases (average 140mg / day) and nadolol (2 cases)