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以毒死蜱为芯材,以生物可降解材料聚乳酸(PLA)为载体(壁材),采用溶剂挥发法制备了毒死蜱缓释微球,考察了芯壁材质量比及聚乳酸浓度对微球质量的影响。结果表明:当聚乳酸浓度增加时,载药量和包封率、粒径均随之增加;当芯壁材质量比减小(由1∶2减小至1∶5)时,微球粒径、载药量也逐渐减小;包封率在芯壁材质量比为1∶3和1∶4时分别为89.88%±1.67%和90.55%±1.86%;当芯壁材质量比小于1∶2时,微球呈光滑完整的球形。差示扫描量热检测分析证明,毒死蜱和聚乳酸能够有机地结合为一体。表明合适的芯壁材比例和聚乳酸浓度有利于提高制备微球的质量。
Taking chlorpyrifos as the core material and the biodegradable material polylactic acid (PLA) as the carrier (wall material), the chlorpyrifos release microspheres were prepared by the solvent evaporation method. The effects of the mass ratio of the core wall material and the polylactic acid concentration on the microsphere quality Impact. The results showed that when the concentration of polylactic acid increased, the drug loading, encapsulation efficiency and particle size both increased. When the mass ratio of core wall material decreased from 1: 2 to 1: 5, Diameter and drug loading decreased gradually. The entrapment efficiency was 89.88% ± 1.67% and 90.55% ± 1.86% when the ratio of core wall material was 1: 3 and 1: 4 respectively. When the ratio of core wall material mass was less than 1 : 2, microspheres are smooth and complete spherical. Differential scanning calorimetry analysis proved that chlorpyrifos and polylactic acid can be combined organically. The results showed that the suitable proportion of core material and polylactic acid concentration could improve the quality of microspheres.