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(一)正常大白鼠盐水負荷时,口服5毫克/公斤HCT,在7次实驗中,有3次实驗表現显著排鉀增多,而另外4次則虽也均有排鉀增高傾向,但統計测驗不显著。推測和各批正常员体內醛固酮水平高低有关。 (二)去腎上腺大白鼠,无論水負荷或盐水負荷,口服5毫克/公斤HCT,在6次实驗中均不能增加鉀排泄,但預先肌肉注射DOCA后,就轉为明显,从而直接証明了ECT的增加排鉀和体內醛固酮水平高低密切相关。 (三)碳酸酐酶抑制剂AAA,在去腎上腺大白鼠仍能表現其增加排鉀的作用,而加用DOCA后就更加明显,可見碳酸酐酶抑制及醛固酮均为影响远端腎小管鈉鉀交换的因素,但其中任何一个因素都非唯一因素,两者作用机制不同,却都能促进鈉鉀交换,故当两者同时存在时,排鉀作用就表現得最为明显。 (四)醛固酮对抗剂SL能糾正利尿药因加用DOCA后引起的排鉀作用,但不能直接对抗AAA所产生的排鉀增多,再次証明SL在鉀排泄上和DOCA也起着专一性的竞爭性对抗作用。
(1) HCT was orally administered at a dose of 5 mg / kg orally in normal rats during saline loading, with significant increases in potassium excretion in 3 of the 7 experiments, and an increase in potassium excretion in the other 4 times, but statistical tests Not obvious. Presumably, the level of aldosterone in normal volunteers was related to the level of aldosterone. (B) Rat adrenal glands, irrespective of water load or saline load, orally administered 5 mg / kg HCT, did not increase potassium excretion in all 6 experiments, but became apparent after pre-intramuscular injection of DOCA, thus directly demonstrating ECT increased row of potassium and body aldosterone levels are closely related. (C) carbonic anhydrase inhibitor AAA, adrenal rats can still show its role in increasing the role of potassium discharge, and after adding DOCA even more obvious, we can see carbonic anhydrase inhibition and aldosterone are the impact of distal tubular sodium potassium However, none of the factors is the only factor. The mechanism of action of both is different, but both can promote the exchange of sodium and potassium. Therefore, when both exist, the role of the row of potassium is most obvious. (D) aldosterone antagonist SL can correct the diarrhea caused by the addition of DOCA potassium row, but can not directly against the AAA row of potassium increased, once again proved that SL and potassium in the DOCA also play a special Competitive antagonism.